Abstract the Future of Science Ep. 42 – Counteracting CRISPR ft. Ada McVean

39 minute read

Our guest this week, Ada McVean, is pursuing a Master’s of Chemistry at McGill University in the Damha Lab (alongside our good friend James Thorpe from Ep. 30!). Her current research is focused on creating small modified nucleic acid-based inhibitors (or SNuBs) of Cas9 using click chemistry, to interrupt the normal functioning of the CRISPR complex. Questions Answered Why might we want to prevent a CRISPR complex from editing our genes? How do SNuBs interrupt a ribunucleic threesome? If gene editing is a play, who are the characters and what sorts of hijinx do they get themselves into? Can Turtles breathe out of their butts? How do lava lamps produce their magically entrancing goopy light show? Will wearing a hat speed up the balding process? and many, many, many more!

Listen here: https://open.spotify.com/episode/5OCtjggihVNQVNQckMgsdx?si=U3V5arJnQeODCw_DR9kVsw&utm_source=copy-link&nd=1